Table II. Genes implicated in familial Parkinson's disease. AD, autosomal dominant; AR, autosomal recessive; LB, Lewy body; DAT, dopamine transporter; TH, tyrosine hydroxylase.

Gene	Locus	Inheritance	Onset	LB pathology	Product	Properties	Functional role	Found in LBs
PARK1	4q21	AD	Late	Yes	α-Synuclein	Presynaptic	Vesicle maintenance?	Yes
						protein	Plasticity?
PARK2	6q25-27	AR	Early	No	Parkin	E3 ubiquitin ligase	Preproteolytic	Yes
							ubiquitination
PARK5	4p14	AD	Late	Unknown	UCH-L1	Ubiquitin C-terminal	Ubiquitin removal	Yes
						hydroxylase L1	for recycling
PARK7	1p36	AR	Early	Unknown	DJ-1	Antioxidant?	Oxidative stress	No
						Molecular chaperone?	response?
NR4A2	2q22-23	AD	Late	No	NURR1	Transcription factor	Dopaminergic	No
						for DAT and TH	neurogenesis