Table I. Summary of the changes in neuroactive steroids and their precursors in rats, monkeys, and healthy human subjects induced by acute ethanol administration or by acute stress or HPA stimulation. These effects are described and referenced in the text. ↑ = increase; ↓ = decrease; -- = unchanged; na = not assayed; HPA axis; activation by naloxone, CRF, or ACTH; 3α,5α-THDOC, 3α,21-dihydroxy-5α-pregnan-20-one; 3α,5α-THP, 3α-hydrcxy-5α-pregnan-20-one; DOC, deoxycorticosterone; HPA, hypothalamic-pituitary-adrenal; CRF, corticotropin-releasing factor;
Pregnenolone | Progesterone | 3α,5α-THP | DOC | 3α,5α-THDOC | |
Rats | |||||
Acute ethanol | ↑ | ↑ | ↑ | ↑ | ↑ |
Acute stress | ↑ | ↑ | ↑ | NA | ↑ |
Monkeys | |||||
Acute ethanol | -- | NA | NA | -- | NA |
Acute stress/HPA axis | ↑/-- | --/↓ | NA | ↑ | NA |
Humans | |||||
Acute ethanol | ↑ | ↑/↓ | ↑/--/↓ | NA | NA |
Acute stress/HPA axis | ↑ | ↑ | ↑ | ↑ | NA |