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. 2006 Dec;8(4):463–477. doi: 10.31887/DCNS.2006.8.4/amorrow

Table I. Summary of the changes in neuroactive steroids and their precursors in rats, monkeys, and healthy human subjects induced by acute ethanol administration or by acute stress or HPA stimulation. These effects are described and referenced in the text. ↑ = increase; ↓ = decrease; -- = unchanged; na = not assayed; HPA axis; activation by naloxone, CRF, or ACTH; 3α,5α-THDOC, 3α,21-dihydroxy-5α-pregnan-20-one; 3α,5α-THP, 3α-hydrcxy-5α-pregnan-20-one; DOC, deoxycorticosterone; HPA, hypothalamic-pituitary-adrenal; CRF, corticotropin-releasing factor;

Pregnenolone Progesterone 3α,5α-THP DOC 3α,5α-THDOC
Rats
Acute ethanol
Acute stress NA
Monkeys
Acute ethanol -- NA NA -- NA
Acute stress/HPA axis ↑/-- --/↓ NA NA
Humans
Acute ethanol ↑/↓ ↑/--/↓ NA NA
Acute stress/HPA axis NA