| 1p35-p36 |
(DSM-IV) BP-I, BP-II, SABP, or recurrent MD |
Schumacher J et al |
59 |
(NPL=3.97)*** |
| 1q31-q32 |
BP-I, BP-II with major depression, SCA, and UPR |
Detera-Wadleigh SD et al |
20 |
2.67 |
| 1q42 (D1S2800) |
(DSM-IV) SABP, BP-I, or SC |
Hamshere ML et al |
58 |
3.54 |
| 2p13-16 |
BP-I or SCA-manic type |
Liu J et al |
44 |
3.20 |
| 2q24 |
SCA-manic type, BP-I, BP-II with recurrent MD |
Zandi PP et al |
60 |
1.99 |
| 3q14 (D3S1300) |
BP-I or BP-II or SABP, regardless of age of onset, or if they had a major depressive episode with an age of onset of ≤21 |
Etain B et al |
61 |
(NPL=3.51)*** |
| 3p21 (D3S1285) |
BP-I |
Mclnnes LA et al |
27 |
2.26 |
| 3q28 (D3S2418) |
SCA-manic type, BP-I, BP-II with recurrent MD, or MDD-R |
Zandi PP et al |
60 |
1.94 |
| 4p (D4S394) |
BP-I and BP-II |
Blackwood DH et al |
18 |
4.1 |
| 4q12-q21 (D4S392) |
BP-I, BP-II with MD, SCA, and UPR including individuals with 2 or more episodes of MD |
Detera-Wadleigh SD et al |
20 |
1.77 |
| 4q21 |
BP-I, BP-II, SCA and recurrent MD |
Cassidy F et al |
37 |
(NPL-2.23)*** |
| 4q31 (D4S1625) |
BP-I or SCA-manic type |
Liu J et al |
29 |
3.16 |
| 4q31 |
(DSM-IV) BP-I, BP-II, SABP, or recurrent MD |
Schumacher J et al |
59 |
(NPL=5.49)*** |
| 4q35 (between D4S3051-4qTEL13) |
BP-I, BP-II, SCA-manic type, or UPR |
Badenhop RF et al |
62 |
3.2 |
| Chrom 5 (D5S207) |
BP-I or SABP, BP-II with recurrent depression, plus UPR |
Dick DM et al |
63 |
2.8 |
| 5q31-33 (D5S2049) |
BP-I |
Herzberg I et al |
30 |
(NPL=4.395)*** |
| 5q33-34 (GABRA1) |
BP-I or SCA with presence of hallucinations and delusions |
Kerner B et al |
31 |
(P<0.00001) |
| Chrom 6 (108.5 Mb) |
(DSM-IV, RDC, DSM-III-R) BP-I only |
McQueen MB et al |
32 |
4.19 |
| 6p (D6S7) |
BP-I (RDC) |
Ginns El et al |
33 |
2.2 |
| 6q (D6S1021) |
BP-I, SABP, BP-II, or UPR |
Disk DM et al |
36 |
3.61 |
| 6q16-q21 (D6S1021) |
(DSM-IV) BP-I, BP-II, BP-NOS, MDD-R |
Lambert D et al |
47 |
2.62 |
| 6q22 |
(DSM-IV) BP-I or SABP |
Pato CN et al |
34 |
3.56 (NPL=4.20)*** |
| 6q24 |
(DSM-IV) BP-I, BP-II, SABP, or reccurent MD |
Schumacher J et al |
59 |
(NPL=4.87)*** |
| 7p (between D7S1802- D7S1869) |
BP-I, BP-II, and SCA or UPR (RDC and DSM III-R) |
Detera-Wadleigh SD et al |
64 |
(P≤ 0.05)* |
| 7q31 (between D7S1799-D7S501) |
BP-I, BP-II with MD, and SCA or individuals with two or more episodes of MD |
Detera-Wadleigh SD et al |
20 |
2.08 |
| 7q34 (D7S1824) |
BP-I or SCA-manic type or BP-II |
Liu J et al |
29 |
2.78 |
| 7q36 |
BP-I, BP-II, SCA, recurrent MD |
Cassidy F et al |
37 |
(NPL=2.11)*** |
| Chrom 8 (135.4Mb) |
DSM-IV, RDC, DSM-III-R) BP-I only |
McQueen MB et al |
32 |
1.99 |
| 8q (D8S256) |
BP-I or SABP |
Disk DM et al |
36 |
2.46 |
| 8q24 (D8S284) |
Female participants with history of puerperal psychosis, defined as a mania or psychosis with onset within 6 weeks of delivery |
Jones I et al |
65 |
2.03 |
| 8q24 (D8S256) |
Included BP-I, BP-II with UPR, and SABP |
McInnis M et al |
66 |
2.1 |
| 8q24.21-qter |
BP-I or SABP |
Segurado R et al |
35 |
(PAvgRnk≤0.05)** |
| Chrom 9 (24.5 Mb) |
(DSM-IV, RDC-III-R) BP-I only |
McQueen MB et al |
32 |
2.04 |
| 9p21-q21 |
BP-I, BP-II, SCA and recurrent MD |
Cassidy F et al |
37 |
NPL=2.41)*** |
| 9p21.1-q21.1 |
BP-I or SABP |
Segurado R et al |
35 |
(PAvgRnk≤0.05)** |
| Chrom 10 ( D10S1423) |
SABP, BP-I, and BP-II |
Foroud T et al |
68 |
2.5 |
| 10p (between INS and HRAS1) |
(RDC) BP-I, BP-II, SCA (manic-depressive type), atypical psychosis with prominent affective features, and Unipolar MD |
Egeland et al |
56 |
4.904 (note: further analysis of this data set yielded negative LOD scores in this region) |
| 10p12 (D10S1423) |
BP-I, SABP, and BP-II |
McInnis M et al |
67 |
2.2 |
| 10q11.21-q22.1 |
BP-I or BP-I and SABP |
Segurado R et al |
35 |
(PAvgRnk=.008)** |
| 10q24 (D10S169) |
manic syndrome, mostly BP-I |
Liu J et al |
29 |
2.79 |
| 10q25-q26 (D10S217) |
BP-I, BP-II with major depression, and SCA and those individuals with two or more episodes of MD |
Cichon et al |
70 |
2.86 |
| 10q26 (D10S217) |
included bipolar disorder, single episode mania or SCA, manic and depressed type |
Ewald et al |
69 |
2.17 |
| 11p15.5 (between D11S1984-D11S2362) |
(DSM-III-R and RDC) SABP, BP-I, and BP-II |
Zandi PP et al |
41 |
(NPL = 2.19 near marker D11S1923, peak HLOD of 2.00)*** |
| 12q23-q24 |
BP-I, SABP, BP-II, and UPR |
Morissette J et al |
72 |
1.327 |
| 12q24 (D12S378) |
BP-I, SABP and BP-II recurrent episode, and recurrend MD |
Shink E et al |
71 |
3.35 |
| 12q24 |
BP-I only |
Cassidy F et al |
37 |
(NPL=2.20)*** |
| 13q |
“SCA, BP-I and BP-II, and narrower models” |
Badner JA et al |
74 |
(MSP=6x10-6)' |
| 13q14-32 |
SABP or BP-I |
Stine OC et al |
38 |
1.12 |
| 13q31 (D13S317) |
All subjects with a mood disorder |
Potash JB et al |
75 |
2.52 (NPL=3.56)*** |
| 13q31-q34 |
BP-I, BP-II, SABP and recurrent MD |
Kelsoe JR et al |
73 |
2.4 |
| 13q32 (between D13S1252-D13S1271) |
BP-I, BP-II with MD, SCA and individuals with two or more episodes of MD |
Detera-Wadleigh SD et al |
20 |
3.5 |
| 13q32 (near D13S779) |
manic syndrome, mostly BP-I, plus BP-II |
Liu J et al |
29 |
2.2 |
| 14q24 (D15S1014) |
BP-I only |
Cassidy F et al |
37 |
(NPL=3.27)*** |
| 15q26 (D15S1014) |
(DSM-IV) SC, SCA, Bipolar Disorder |
Vazza G et al |
39 |
(NPL=3.05)*** |
| Chrom 16 (D16S749) |
BP-I or SABP, BP-II with recurrent depression, and UPR |
Dick DM et al |
63 |
2.8 |
| 16p13 |
BP-I only |
Cassidy F et al |
37 |
(NPL=2.23)*** |
| 16p13 (D16S423) |
Female participants with history of puerper al psychosis (see above) |
Jones I et al |
65 |
4.07 |
| 17q (D17S928) |
BP-I, SABP, BP-II and UPR |
Dick DM et al |
36 |
3.63 |
| 17q11-12 (D17S921) |
manic syndrome, mostly BP-I |
Liu J et al |
29 |
2.68 |
| Chrom 18 (D18S21) |
SCA, BP-I, and BP-II with major depression and UPR |
Berrettini WH et al |
26 |
2.38 |
| 18pter-p11 and 18p11-q12.3 |
BP-I, SABP BP-II, and recurrent major depressive disorder |
Segurado R et al |
35 |
(PAvgRnk≤0.05)** |
| 18p11.2 (between D18S1150-D18S71) |
BP-I, BP-II, with MD, and SCA |
Detera-Wadleitgh SD et al |
20 |
2.32 |
| 18q22-23 (D18S61) |
BP-I |
McInnes et al. |
27 |
2.26 |
| 19q13 (D19S221) |
(DSM-IV) SABP, BP-I, or SC |
Hamshere ML et al |
58 |
1.85 |
| Chrom 20 (4.5 Mb) |
(DSM-IV, RDC, DSM-III-R) BP-I only |
McQueen MB et al |
32 |
1.91 |
| 20p12 (D20S162) |
BP-I, BP-II, SABP, and UPR |
Willour VL et al |
77 |
1.82 (nonparametric LOD score of 2.38) |
| 21q22 (PFKL locus) |
(RDC) Bipolar disorder or recurrent MD |
Straub RE et al |
24 |
3.41 |
| 21q (D21S212) |
BP-I and BP-II, with major depression and schizoaffectives |
Detera-Wadleigh SD et al |
78 |
1.79 |
| 21q22 (D21S1260) |
BP-I, unipolar manic, SCA, BP-II, plus UPR and recurrent unipolar and “individuals who do not quite meet criteria but ar judged to possibly have above diagnoses” |
Liu J et al |
76 |
3.56 |
| 22q |
“SCA, bipolar I and bipolar II, and narrower models” |
Badner JA et al |
74 |
(MSP=3x10-5)' |
| 22q11 (D22S420) |
(DSM-IV) SABP, BP-I or SC |
Hamshere ML et al |
58 |
1.96 |
| 22q12 (D22S278) |
(DSM-III-R) BP-I, BP-II, SABP, and recurrent MD |
Kelsoe JR et al |
73 |
3.84 |
| 22q12-13 (D22S277) |
All subjects with a mood disorder |
Potash JB et al |
75 |
3.06 |
| Xp22 and Xq26-28 |
SABP, BP-I anf SABP, BP-I, BP-II (respectively) |
Stine O et al |
38 |
0.94 and 1.34 (respectively) |
| Xp11.3 (GATA144D04) |
(DSM-III-R) SABP and BP-I |
Zandi PP et al |
41 |
(NPL=2.19; HLOD=2.25)*** |
| Xq24-q26 (DXS994) |
BP-I, BP-II, BP-NOS or SCA |
Pekkarinen P et al |
40 |
3.54 |
