Figure 1. Brain responses during risky decision-making in patients with mania, patients with depression, and healthy controls. A: Screen display for the Risk Task. Subjects are instructed that a token has been hidden at random under one of the six boxes. They must guess whether the token is hidden under a red or blue box, in order to win points. The less likely option (blue, in this example) is also associated with a higher win value, to create conflict between reward and uncertainty. Blocks of decision-making were contrasted with a visuomotor baseline condition. B: Activations during decision-making in healthy controls. C: Activations during decision-making in patients with mania. D: Activations during decision-making in patients with major depressive disorder. E: Areas of increased activity in healthy controls relative to patients with mania. Reproduced from ref 68: Rubinsztein JS, Fletcher PC, Rogers RD, et al. Decision-making in mania; a PET study. Brain. 2001;124:2550-2263. Copyright © Oxford University Press 2001 .