Skip to main content
. 2010 Mar;12(1):85–93. doi: 10.31887/DCNS.2010.12.1/mnoethen

Table I. Published genome-wide association studies (GWASs) for schizophrenia.21-30,32 The number of variants investigated, the best associated single-nucleotide polymorphism(s)-SNP(s) - found and the gene(s) containing the SNP(s), the corresponding Pvalue(s), and the number of cases and controls in the discovery and the replication/meta-ana lysis sample are all given. Genome-wide significant findings are highlighted in bold EA, European Ancestry Individuals; AA, African-American Individuals; ND, no data available; NR, no replication .

Study SNPs analyzed Supported gene Supported variant Genomic region P value discovery N° samples discovery P value combined replication/ meta-analysis
Mah et al -(2006) ~ 25000 plexin A2 (PLXNA2) rs752016 1q32.2 0.006 320 cases 0.035 200 cases (EA)
325 controls 230 controls (EA)
Lencz et al (2007) ~ 500000 colony stimulating rs4129148 Xp22.33 3.7 x10-7 178 cases ND ND
factor receptor 2 Yp22.32 144 controls
alpha (CSF2RA)
Sullivan et al (2008) ~ 500000 nearest gene: rs4846033 1p36.22 4.4x10-6 738 cases ND ND
angiotensin II receptor- 733 controls
associated protein
(AGTRAP)
O'Donovan et al (2008) ~ 500000 zinc finger protein rs1344706 2q32.1 1.8x10-6 479 cases 1.6 x10-7 7308 cases
804A (ZNF804A) 2937 controls 12834 controls
Shifman et al (2008) ~ 500000 reelin (RELN) rs7341475 7q22.1 2.9x10-5 745 cases 8.8 x10-7 2274 cases
(in females) 2644 controls (in females) 4401 controls
Kirov et al (2009) ~ 550000 coiled coiled domain rs11064768 12q24.23 1.2x10-6 574 trios ND
containing 60 (CCDC60)
Need et al (2009) ~ 550000 ADAMTS like 3 rs2135551 15q25.2 1.3x10-6 871 cases NR 1460 cases
(ADAMTSL3) 863 controls 12995 controls
Shi et al (2009) ~ 600000 ArfGAP with GTPase rs13025591 2q37.2 4.6 x10-7 2681 cases ND
domain, ankyrin repeat (in EA) 2653 controls
and PH domain 1 (EA)
(AGAP1)
v-erb-a erythroblastic rs1851196 2q34 2.1x10-6 1286 cases ND
leukemia viral oncogene (inAA) 973 controls
homolog 4 (avian) (AA)
(ERBB4)
major histocompatibility rs9272219 6p21.32 ND 6.9 x10-8 8008 cases (EA)
complex (MHC rs9272535 6p21.32 ND 8.9 x10-8 19077 controls (EA)
cluster of histone rs13194053 6p22.1 1.4x10-2 9.5 x10-9
protein genes (in EA)
The ~ 1000000 myosin XVIIIB rs5761163 22q12.1 3.4 x10-7 3322 cases ND 8008 cases
International (MYO18B) 3587 controls 9.5 x10-9 19077 controls
Schizophrenia major histocompatibility rs13194053 6p22.1 ND
Consortium (2009) complex (MHC)
Stefansson et al -(2009) ~ 300000 major histocompatibility 5 variants 6p21.3- 0.0027- 2663 cases 1.1x10-9- 12945 cases
complex (MHC) 6p22.1 0.00023 13498 controls 1.4x10-12 34591 controls
neurogranin (NRGN) rs12807809 11q24.2 0.00045 2.4x10-9
transcription factor 4 rs9960767 18q21.1 0.0011 4.1 x 10-9
(TCF4)
HHS Vulnerability Disclosure