Table I. Published genome-wide association studies (GWASs) for schizophrenia.21-30,32 The number of variants investigated, the best associated single-nucleotide polymorphism(s)-SNP(s) - found and the gene(s) containing the SNP(s), the corresponding Pvalue(s), and the number of cases and controls in the discovery and the replication/meta-ana lysis sample are all given. Genome-wide significant findings are highlighted in bold EA, European Ancestry Individuals; AA, African-American Individuals; ND, no data available; NR, no replication .
| Study | SNPs analyzed | Supported gene | Supported variant | Genomic region | P value discovery | N° samples discovery | P value combined | replication/ meta-analysis |
| Mah et al -(2006) | ~ 25000 | plexin A2 (PLXNA2) | rs752016 | 1q32.2 | 0.006 | 320 cases | 0.035 | 200 cases (EA) |
| 325 controls | 230 controls (EA) | |||||||
| Lencz et al (2007) | ~ 500000 | colony stimulating | rs4129148 | Xp22.33 | 3.7 x10-7 | 178 cases | ND | ND |
| factor receptor 2 | Yp22.32 | 144 controls | ||||||
| alpha (CSF2RA) | ||||||||
| Sullivan et al (2008) | ~ 500000 | nearest gene: | rs4846033 | 1p36.22 | 4.4x10-6 | 738 cases | ND | ND |
| angiotensin II receptor- | 733 controls | |||||||
| associated protein | ||||||||
| (AGTRAP) | ||||||||
| O'Donovan et al (2008) | ~ 500000 | zinc finger protein | rs1344706 | 2q32.1 | 1.8x10-6 | 479 cases | 1.6 x10-7 | 7308 cases |
| 804A (ZNF804A) | 2937 controls | 12834 controls | ||||||
| Shifman et al (2008) | ~ 500000 | reelin (RELN) | rs7341475 | 7q22.1 | 2.9x10-5 | 745 cases | 8.8 x10-7 | 2274 cases |
| (in females) | 2644 controls | (in females) | 4401 controls | |||||
| Kirov et al (2009) | ~ 550000 | coiled coiled domain | rs11064768 | 12q24.23 | 1.2x10-6 | 574 trios | ND | |
| containing 60 (CCDC60) | ||||||||
| Need et al (2009) | ~ 550000 | ADAMTS like 3 | rs2135551 | 15q25.2 | 1.3x10-6 | 871 cases | NR | 1460 cases |
| (ADAMTSL3) | 863 controls | 12995 controls | ||||||
| Shi et al (2009) | ~ 600000 | ArfGAP with GTPase | rs13025591 | 2q37.2 | 4.6 x10-7 | 2681 cases | ND | |
| domain, ankyrin repeat | (in EA) | 2653 controls | ||||||
| and PH domain 1 | (EA) | |||||||
| (AGAP1) | ||||||||
| v-erb-a erythroblastic | rs1851196 | 2q34 | 2.1x10-6 | 1286 cases | ND | |||
| leukemia viral oncogene | (inAA) | 973 controls | ||||||
| homolog 4 (avian) | (AA) | |||||||
| (ERBB4) | ||||||||
| major histocompatibility | rs9272219 | 6p21.32 | ND | 6.9 x10-8 | 8008 cases (EA) | |||
| complex (MHC | rs9272535 | 6p21.32 | ND | 8.9 x10-8 | 19077 controls (EA) | |||
| cluster of histone | rs13194053 | 6p22.1 | 1.4x10-2 | 9.5 x10-9 | ||||
| protein genes | (in EA) | |||||||
| The | ~ 1000000 | myosin XVIIIB | rs5761163 | 22q12.1 | 3.4 x10-7 | 3322 cases | ND | 8008 cases |
| International | (MYO18B) | 3587 controls | 9.5 x10-9 | 19077 controls | ||||
| Schizophrenia | major histocompatibility | rs13194053 | 6p22.1 | ND | ||||
| Consortium (2009) | complex (MHC) | |||||||
| Stefansson et al -(2009) | ~ 300000 | major histocompatibility | 5 variants | 6p21.3- | 0.0027- | 2663 cases | 1.1x10-9- | 12945 cases |
| complex (MHC) | 6p22.1 | 0.00023 | 13498 controls | 1.4x10-12 | 34591 controls | |||
| neurogranin (NRGN) | rs12807809 | 11q24.2 | 0.00045 | 2.4x10-9 | ||||
| transcription factor 4 | rs9960767 | 18q21.1 | 0.0011 | 4.1 x 10-9 | ||||
| (TCF4) |