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. 2010 Mar;12(1):85–93. doi: 10.31887/DCNS.2010.12.1/mnoethen

Table II. Published genome-wide association studies (GWASs) for bipolar disorder.34-39 The number of variants investigated, the best associated singlenucleotide polymorphism(s)-SNP(s) - found and the gene(s) containing that SNP(s), the corresponding Pvalue(s), and the number of cases and controls in the discovery and the replication/meta-analysis sample are all given. Genome-wide significant findings are highlighted in bold EA, European Ancestry Individuals; AA, African-American Individuals; ND, no data available; NR, no replication .

Study N° SNPs Supported Supported Genomic P value samples. P value N° samples.
analyzed gene variant region discovery discovery combined replication/
meta-analysis
Baum et al ~ 550 000 diacylglycerol kinase rs1012053 13q14.11 0.0002 461 cases 1.5x10-8 772 cases
(2007) eta (DGKH) 563 controls 876 controls
Welcome Trust ~ 500 000 partner and localizer rs42059 7q21.3 6.3 x10-8 1868 cases ND ND
Case Control Of BRCA2 (PALB2) 2938 controls
Consortium
(WTCCC; 2007)
Sklar et al ~ 400 000 tetraspanin-8 (TSPAN8) rs1705236 12q21.1 6.1x10-7 1461 cases NR
(2008) myosin5B (MYO5B) rs4939921 18q21.1 1.7 x10-7 2008 controls NR
voltage-dependent 3329 cases
calcium channel, L-type, rs1006737 12p13.33 8.8x10-4 3.1 x 10-6 4946 controls
alpha K subunit
(CACNA1C)
Ferreira et al ~ 1 800 000 ankyrin G (ANK3) rs10994336 10q21.2 0.0002 1098 cases 9.1 x 10-9 4387 cases
(2008) (imputed) rs1938526 10q21.2 0.0002 1267 controls 1.3x10-8 6209 controls
~ 300 000 voltage-dependent rs1006737 7.0 x10-8
(genotyped) calcium channel, L-type, 12p13.33 0.0108
alpha K subunit
(CACNA1C)
Scott et al ~ 550 000 inter-alpha (globulin) rs1042779 3p21.1 2076 cases 1.8 x10-7 3683 cases
(2009) inhibitor H1 (ITIH1) 1676 controls 14507 controls
multiple C2 domains, rs17418283 5q15 ND
transmembrane 1 1.3 x10-7
(MCTP1)
nuclear factor 1 A-type rs472913 1p32.1 2.0 x10-7
(NF1A)
Smith et al ~ 700 000 nck-associated protein 5 rs10193871 2q21.2 9.8x10-6 1001 cases ND ND
(2009) (NAP5) 1033 controls
(EA)
dpy-19-like 3 (DPY19L3) rs2111504 19q13.11 1.5x10-6 345 cases
670 controls
(AA)
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