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. 2010 Jun;12(2):149–163. doi: 10.31887/DCNS.2010.12.2/dpauls

Table III. Candidate gene studies of OCD. *Association with the hoarding phenotype.

Adapted from ref 134 (and updated through 11/2009): Hanna GL, Veenstra-VanderWeele J, Cox NJ, et al. Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet. 2002; 114:541-552. Copyright © Wiley-Liss 2002

Candidate gene Investigator Study design Sample size Significance Associated allele
Serotonin transporter Cases Controls Families
McDougle et al86 FB - --- 35 P<0.03 Lallele
Bengel et al87 CC 75 397 --- P=0.023 LL genotype
Frisch et al88 CC 75 172 --- ns ---
Kinnear et al89 CC 54 82 --- ns ---
Denys et a l90 CC 156 134 --- ns ---
Dickel et al91 FB --- --- 54 ns ---
Saiz et al92 CC 99 420 - ns ---
Wendland et al93 CC 347 749 --- ns ---
Wendland et al84 CC 295 657 - P<0.018 3 marker haplotype
Serotonin transporter promoter
Kinnear et al94 CC 129 479 --- ns ---
Camarena et al95 CC/FB 115 136 43 ns ---
Cavallini et al96 CC 180 112 --- ns ---
Walitza et a l97 FB --- --- 63 ns ---
Meira-Lima et al98 CC 79 202 --- ns ---
Chabane et al99 CC/FB 106 171 86 ns ---
Serotonin receptor 2A
Nicolini et al100 CC 67 54 --- ns ---
Enoch et al101 CC 62 144 --- P<0.05 A allele
Enoch et al102 CC 101 138 --- P=0.015 A allele
Frisch et al88 CC 75 172 --- ns ---
Walitza et al103 CC 55 223 --- ns ---
Hemmings et al104 CC 71 129 --- ns ---
Tot et al105 CC CC? 77 --- ns ---
Hemmings et al106 CC 58 83 --- ns ---
Meira-Lima et al98 CC 79 202 --- P<0.00007 C-Allele
Denys et al90 CC 156 134 --- ns ---
Dickel et al91 FB --- --- 54 ns ---
Saiz et al92 CC 99 420 --- P=0.02 ---
Serotonin receptor 2C
Cavallini et al107 CC 109 107 --- ns ---
Frisch et al88 CC 75 172 --- ns ---
Meira-Lima et al98 CC 79 202 --- ns ---
Cavallini et al107 CC 109 107 --- ns ---
Frisch et al88 CC 75 172 --- ns ---
Meira-Lima et al98 CC 79 202 --- ns ---
Serotonin receptor 1B (1 Dβ)
Mundo et al108 FB --- --- 32 P<0.006 G allele
Mundo et al109 FB --- --- 121 P=0.023 G allele
DiBella et al110 FB --- --- 48 ns ---
Hemmings et al104 CC 77 129 --- ns ---
Camarena et al111 FB --- --- 47 ns ---
Walitza et al97 FB --- --- 63 ns ---
Denys et al90 CC 156 134 --- ns ---
Dickel et al91 FB - --- 54 ns ---
Tryptophan hydroxylase
Frisch et al88 CC 75 172 --- ns ---
Walitza et al97 FB - --- 63 ns ---
Mössner et al112 FB --- --- 71 P=0.035 G-C Haplotype
Dopamine receptor 4
Cruz et al113 CC 12 49 --- P= 0.018
Billet et al114 CC 118 118 --- P= 0.021
Frisch et al88 CC 75 172 --- P=0.04 7 allele less frequent
Millet et al115 CC/FB 49 63 34 P=0.03 2 allele protective
Hemmings et al104 CC 71 129 --- ns ---
Hemmings et al106 CC 95 85 --- P=0.013 early vs late onset
Dopamine receptor 2
Nicolini et al100 CC 67 54 --- ns ---
Billet et al114 CC 110 110 --- P=0.014 CC genotype
Dopamine receptor 3
Catalanoet al116 CC 97 97 --- ns ---
Nicolini et al100 CC 67 54 --- ns ---
Billet et al114 CC 103 103 --- ns ---
Dopamine transporter
Billet et al114 CC 103 103 --- ns ---
Frisch et al88 CC 75 172 --- ns ---
Hemmings et al104 CC 71 129 --- ns ---
Dopamine receptor 2
Nicolini et al100 CC 67 54 --- ns ---
Billet et al114 CC 110 110 --- P=0.014 CC genotype
Dopamine receptor 3
Catalano et al116 CC 97 97 --- ns ---
Nicolini et al100 CC 67 54 --- ns ---
Billet et al114 CC 103 103 --- ns ---
Dopamine transporter
Billet et al114 CC 103 103 --- ns ---
Frisch et al88 CC 75 172 --- ns ---
Hemmings et al104 CC 71 129 --- ns ---
Monamine oxidase A
Karayiorgou et al117 FB --- --- 110 P=0.019(males) G allele
Camarena et al95 CC/FB 122 124 51 CC: P=0.024 FB: P=0.022 T allele
Hemmings et al104 CC 71 129 --- ns ---
Catechol O-methyl transferase
Karayiorgou et al118 CC 73 148 --- P=0.0002 L allele in males
Karayiorgou et al117 FB --- --- 110 P=0.0079 L allele
Schindler et al119 FB --- --- 67 P=0.006 L allele
Niehaus et al120 CC 54 54 --- P=0.0017 HL genotype
Alsobrook et al121 FB - --- 56 P=0.04S L allele in females
Ohara et al122 CC 17 35 --- ns ---
Erdal et al123 CC 59 114 --- ns ---
Azzam et al124 CC 144 337 --- ns ---
Meira-Lima et al98 CC 79 202 --- ns ---
Katerberg et al125 CC 373 462 --- ns ---
Glutamate receptor subtype 2B Arnold et al126 FB - - 130 P=0.002 5072G-5988T haplotype
Kainite glutamate receptor 2 Delorme et al127 CC/FB 156 156 141 CC:ns FB: P=0.03 867I allele undertransmitted
Gamma-Amino-butyric acid type B receptor 1 Zai et al128 FB - - 159 P=0.006 A-7265G
Brain-derived neurotropic factor
Hall et al129 FB - --- 164 P<0.020 Multiple SNPs
Dickel et al91 FB - --- 54 ns ---
Wendland et al93 CC 347 749 --- ns ---
Myelin oligo-dendrocyte
Zai et al130 FB --- --- 160 P=0.022 MOG4 2-repeat allele
Glutamate transporter
Arnold et al81 FB --- --- 157 P=0.006 2 marker haplotype (males)
Dickel et al82 FB --- --- 71 P=0.030 2 marker haplotype (males)
Stewart et al83 FB --- --- 66 P=0.0015 3 marker haplotype
Wendland et al84 CC 325 662 --- P<0.001 3 marker haplotype
Oligo-dendrocyte lineage transcription factor 2 Stewart et al131 FB - - 66 P=0.004 5 marker haplotype
Neurotrophin-3 receptor gene (NTRK3)* Muiños-Gimeno et al132 CC 153 324 - P=0.005 -
Extraneuronal monoamine transporter, EMT (SLC22A3) Lazar et al133 CC 84 204 ns -