Table V. Antidepressant augmentation with T4. T3, tri-iodothyronine; T4, thyroxine; RCT, randomized controlled trial; SSRI, selective serotonin reuptake inhibitor.

Study	N	Patients	T4 Dose (µg/day)	Design	Response
Joffe and Singer, 199036	38	Unipolar major depression	150	Double-blind vs T3	4 of 21 responded to T4, T4 < T3
Bauer et al, 199848	17	Unipolar (or) bipolar depression	300-500	Open	10 of 17 showed full or partial response
Spoov and Lahdelma, 199849	22	Major depression	200	Crossover vs lithium	T4 > lithium
Rudas et al, 199950	9	Chronic depression and dysthymia	150-300	Open	6 of 9 full or partial response
Lojko and Rybakowski, 200751	17	Unipolar and bipolar depression	100	Open, on SSRI	11 remission and 16 response