Table VI. Testosterone treatment of depression.

Study	Subjects	Design	Testosterone	Antidepressant	Result
Seidman and Rabkin, 199866	5 men Low testosterone levels	Open 8 weeks	400 mg im biweekly	Yes	Marked improvement
Seidman et al, 200167	32 men Hypogonadal	RCT 6 weeks	200 mg im q-weekly	Yes	Testosterone=Placebo
Perry et al, 200268	16 Older males	Open 6 weeks	200 mg vs 100 mg qweekly	No	No dose effect Improvement late onset > early onset depression
Pope et al, 200369	22 Low testosterone levels	RCT 8 weeks	Gel 1% 10 g/day	Yes	Testosterone>placebo
Orengo et al, 200570	61 Hypogonadal men >50 y	RCT 12-week crossover	Gel 1% 5 g/day	Yes	Testosterone=placebo
Seidman et al, 200571	26 Healthy adult men	RCT 6 weeks	im	Yes	Testosterone=placebo
Seidman et al, 200972	23 Men, low testosterone Dysthymic	RCT 6 xeeks	im q 10 days	No	Testosterone>placebo
Shores et al, 200973	33 Men >50 y hypogonadal Dysthymic	RCT 12 weeks	Gel 1% 7.5 g/day	Yes	Testosterone>placebo
Pope et al, 201074	100 Adulte men Low testosterone levels	RCT 6 weeks	Gel 1 %	Yes	Testosterone=placebo