Table IV. Most relevant predictors of remission defined as severity and time criteria as proposed by Andreasen et al1 (sorted according to duration of trial). (1) These studies used CGI-Schizophrenia criteria (CGI-SCH overall, positive, negative, cognitive and depressive subscores ≤ 3) instead of the PANSS severity items. (2) * for schizophreniform / schizoaffective disorder and ** for schizophrenia. (3) For schizophrenia only. (4) No Pvalues provided for multivariate model, at least P<0.05. * = significant at P<0.05; ** = P≤0.01; *** = P≤0.001.
| Study | Study duration (in months) | Premorbid, baseline, early improvement and treatment predictors related to symptomatic remission | |||||
| Significant (S) or not significant (NS) predictor of symptomatic remission in multivariate regression models | |||||||
| - = Not assessed | |||||||
| Short(er) duration in untreated psychosis (DUP) | Better premorbid adjustment | Lower psychpathology or illness severity score at baseline | Better functioning level at baseline | Early symptomatic, functional or quality of life improvement/remission | Medication nonadherence during treatment | ||
| Emsley et al18 | 12 | S(2) | NS | S (neg symp)(3) | - | S (symptoms)** | - |
| Rossi et al36 | 12 | - | - | S*** | NS | - | - |
| Caton et al37 | 12 | S(4) | S(4) | S(4) | - | - | - |
| Lambert et al39 | 18 | s* | - | S*** | S** | S (symptoms)*** | - |
| Malla et al45 | 24 | S** | S* | - | - | - | S*** |
| Lambert etal33(1) | 24 | - | - | S*** | S** | S (symptoms)*** | S** |
| Novicketal46(1) | 24 | - | - | S** | S* | - | - |
| Emsley et al3925 | 24 | S(4) | S (education status)(4) | NS | S, (marital status)(4) | S (symptoms)(4) | - |
| Lambert etal47(1) | 36 | - | - | NS | NS | S*** (symptoms) | NS |
| Gasquetetal40(1) | 36 | - | - | S(4) | S, (employment)(4) | - | - |
| Novicketal50(1) | 36 | - | - | S*** | S*** | - | S*** |
| Addington & Addington26 | 36 | NS | S* | S*** | - | - |