Table I. Table I. Serotonin (5-HT) receptors in the human brain: distribution, putative functions, and related pathologies. Pre-RNA *splicing and ° editing variants. For review see also refs 98 to100. X, dorsal motor n of the vagus nerve; ACN, accumbens n; Amy, amygdala; cc, corpus callosum; Ce, cerebellum; CPu, caudate-putamen; Cx, cortex; DRN, dorsal raphe n; Fcx, frontal cortex; Hip, hippocampus; Hyp, hypothalamus; LS, lateral septum; MRN, n, nucleus; SN, subtantia nigra; Tha, thalamus; VTA, ventral tegmental area.

5-HT receptor	Locus	Aminoacid length	Human brain regions	Putative functions	Related clinical interests	Ref
5-HT1A	5q11.2-q13	422	Raphe n hyp, hip, amy, CPu, Cx, Fcx	5-HT activit ermoregulatio eding, stress, pai od, emotion, cognitio arning, memory..	Anxiety/depression, neurodegenerative disorders, schizophrenia	25,147,171
5-HT1B (5-HT1Dß)	6q13	390	SN /VTA, ACN, CPu, ventral pallidum, Cx	5-HT activity mood, feeding	Anxiety/depression, migraine	131,138,172
5-HT1D	1p36.3-34.3	343	CPu, , ventral pallidum, Fcx	5-HT activity, mood, feeding	Anxiety/depression, migraine	173
5-HT1E	6q14-q15	365	CPu, Hyp, Cx	(?)	(?)	See 174
5-HT1F	3p13-p14.1	366	Ce, Hip, Cx	Mood, emotion	Migraine	175
5-HT2A	13q14-q21	471	Dorsal vagal complex,	Mood, respiratory control,	Schizophrenia, anxiety/	110,160,176
			hypoglossal n, inferi vary complex, Tha u, Cx, FCx	feeding, nociception	depression, Tourette's syndromzheimer's didease, anorexia/ bulimia, drug abuse, pain
5-HT2B	2q36.3-q37.1	481	Ce (?), LS (?), Hyp (?) Cx (?)	Brain development (?), feeding (?)	Drug abuse, anxiety (?)	177
5-HT2C	Xq24	458°	Choroid plexus, Ce, DRN, SN, Hyp, Amy, Hip, CPu, ACN, Cx	Mood, impulsivity, feeding, locomotor activity	Anxiety/depressio hizophreni ug abuse, obesity	178
5-HT3A-E subunits	11q23. 1-27.1	510* (5-HT3A)	Dorsal vagal complex, Hip, Amy, CPu	Vomiting reflex, mood,	Nausea, anxiety/depression	103,104
5-HT4	5q34-q36	402*	Hyp, Hip, ACN, CPu	Feeding, reward, cognition	Anorexia, drug abuse, Alzheimer's disease	139,171, 179,180
5-HT5A	7q34-q36	357	Ce, Hyp, Thal, Hip, Cx	Circadian rhythm, sleep, mood, cognition	Schizophrenia (?) anxiety/depression (?)	181
5-HT6	1p36-p35	440	Hip, CPu, Cx, olfactory tubercle	Cognition, learning, memory, feeding	Alzheimer's disease, dementia, obesity	171,182
5-HT7	10q21-q24	479*	Raphe n., Hyp, Tha, Hip, Amy, Cx	Mood, sleep, cognition	Anxiety/depression, schizophrenia.	183