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. 2011 Sep 26;208(10):2055–2067. doi: 10.1084/jem.20110428

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© 2011 Takahashi et al.

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Figure 4. — SOCS1-deficient T_reg cells convert into Th1- and Th17-like cells in vitro. (A) 10⁵ Socs1^+/+ and Socs1^−/− T_reg cells/well were activated with anti-CD3/anti-CD28 beads, 10 ng/ml IL-2, and the indicated cytokines, and IFN-γ and IL-17A were measured by ELISA (***, P < 0.0001). (B) Detection of phosphorylations of STAT1 and STAT3 in T_reg cells with the indicated genotypes by immunoblot (left) and flow cytometry (right; mean fluorescent intensity is indicated in the bar graph; *, P < 0.05; **, P < 0.01). (A and B) Data are representative of five independent experiments. Values represent the mean ± SD.