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. 2011 Mar;11(2):93–109. doi: 10.2174/156652411794859250

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© 2011 Bentham Science Publishers Ltd

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (1). Types of miRNA-mRNA interactions. — Different classes of miRNA target sites are presented in a schematic way. Vertical dashes represent single Watson-Crick pairing. Nucleotides involved in binding have been arbitrarily defined to depict positions of required complementarity between miRNA and mRNA. Seed regions of miRNAs are marked by red color and the adenine at binding position 1 by green. Interactions between mRNA and the 3’ end of miRNA have not been shown because they are sequence-dependent and do not significantly contribute to the miRNA downregulation effect. In the case of 3’-suppelmentary and 3’-compensatory sites two regions of pairing (base pairs colored in blue) force middle mismatches to form a loop structure. Additionally, features of particular site types have been listed.