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Antinociception induced by nicotine (1.5mg kg -1 s.c.) in mouse hot-plate test and lack of antagonism by atropine (5mg kg-1 i.p.) and by HC-3 (1µg per mouse i.c.v.). Saline: open circles; Nicotine: closed squares; Atropine + Nicotine: open squares; HC-3 + nicotine: closed circles. ** P< 0.01; * P<0.05 in comparison with saline controls [81].
