Fig. (15).

Paw pressure test: Effect of acetyl-L-carnitine in the presence of atropine (atr.) or mecamylamine (mec.). Response to noxious stimuli on the ipsilateral paw that underwent CCI respect to the contralateral un-operated paw. Effects of treatments with saline alone, acetyl-Lcarnitine (100mg/kg twice daily for 15 days), atropine (5mg/kg twice daily for 15 days) or co-administration of both. Effects of treatments with saline alone, acetyl-L-carnitine (100 mg/kg twice daily for 15 days), mecamylamine (2mg/kg twice daily for 15 days) or co-administration of ALCAR and mecamylamine. Paw Pressure test was performed 30 min after the last injection. Each value represents the mean of 2 experiments with 12 rats per group. *P < 0.01 versus control (saline + saline) rats. °P < 0.01 versus acetyl-L-carnitine + saline treated rats [143].