Table 1.

Analgesic Effect Induced by Rivastigmine and Donepezil in the Mouse Hot-plate Test and Antagonism Exerted by Scopolamine.

	LICKING Latency in Mice (s)
TREATMENT	Before	After Treatment
	Treatment	30 Min	45 Min	60 Min
SALINE	16.2 ± 1.1	16.3 ± 1.4	15.5 ± 2.0	15.4 ± 1.7
SCOPOLAMINE 0.1	14.3 ± 1.2	15.0 ± 1.8	13.9 ± 2.2	15.6 ± 1.8
RIVASTIGMINE 0.5	15.9 ± 1.5	17.0 ± 1.6	16.1 ± 1.8	15.4 ± 1.6
RIVASTIGMINE 1.0	16.4 ± 1.2	25.7 ± 2.1*	25.9. ± 1.9*	24.8 ± 1.5*
RIVASTIGMINE 2.0	17.1 ± 1.8	21.6 ± 2.8*	35.9 ± 2.7*	35.5 ± 3.6*
DONEPEZIL 5	14.3 ± 1.3	33.2 ± 3.4*	25.9 ± 3.1.*	19.3 ± 2.5
DONEPEZIL 10	13.6 ± 1.4	35.1 ± 3.6*	31.5 ± 2.8*	21.7 ± 2.9*
SCOPOLAMINE +DONEPEZIL 5	14.0 ± 0.9	18.5 ± 2.6ˆ	16.4 ± 2.3ˆ	15.8 ± 1.5

The doses are expressed as mg kg^-1 s.c. There were at least 12 mice per group.

^*P < 0.01, versus saline control mice.

^ˆP < 0.01 versus Donepezil (5 mg kg ^-1 s.c.) treated mice [40].