Table 3.

Pharmacokinetic Parameters of CRLX101 and CPT in Sprague Dawley rats. Values from Reference [23]

Pharmacokinetic Parameter	CPT (1.0 mg/kg CPT)	IT-101 (0.9 mg/kg CPT Equivalents)
		Polymer Bound CPT	Released CPT
Cmax (µg/mL)	0.4	9.1	0.2
Vss (mL)	1306	47.2	n/a
CL (mL/h)	1534	3.4	n/a
Terminal half-life (h)	1.3	17.2	n/a
AUC (µg h/mL)	0.2	66.9	0.2