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Maximum Tolerated Dose (MTD) of CRLX101 on Various Dosing Schedules in Athymic Nude Mice [23]
| Dosing Schedule | MTD (mg/kg) |
|---|---|
| qd x 1 | 24 |
| 5/2/5/2/5 | 3 |
| q4d x 5 | 10 |
| qwk x 3 | 15 |
MTD was defined as the dose level below which animals exhibited a mean body weight loss greater than 20% or greater than 10% of animal deaths in a particular group.
