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An Example Sub-Pocket of Five Different Channels, Showing how the Amino Acids Occupying these Defined Residue Positions Determine the Property of the Corresponding Ligand Moiety
| Channel | Residue Position in Sub-Pocket (Based on KCSA Numbering) | Property of Ligand Moiety Recognized | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 75 | 99 | 100 | 100 | 103 | 104 | 107 | |||
| Kir1.4 | T | T | T | T | E | I | T | Basic amine | |
| hERG | S | G | S | S | Y | A | F | Basic amine/aromatic ring | |
| Cav1.1 | D2 D3 |
G | G | N |
A |
L | L | F | H-bonding |
| Kv1.1 | T | G | V | V | I | A | V | Lipophilic | |
| Kvlqt1 | T | A | V | V | F | A | A | Lipophilic | |
