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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2011 Aug 17;38(5):613–636. doi: 10.1007/s10928-011-9211-7

Table 4.

The results for simulation studies (σCl = σV = σ = 0.3 and w2 = 0.3).

Parameters Gamma
Lognormal
Dose dependent
Normal Normal prop. Normal Normal prop. Normal Normal prop.
Cl (50) 49.4 (44.5, 55.4) 51 (44.8, 58.2) 50.9 (45.3, 57.2) 52.2 (45.9, 59.5) 50.1 (41.9, 56.7) 49 (37.7, 56.2)
V (70) 67.9 (50.4, 89) 66.4 (49.4, 85.5) 70.1 (50.8, 91.1) 69.9 (51.9, 86.5) 70.1 (36.9, 91.8) 68.7 (37.1, 88.2)
σCl (0.3) 0.3 (0.23, 0.41) 0.32 (0.23, 0.61) 0.31 (0.23, 0.44) 0.32 (0.24, 0.42) 0.34 (0.24, 1.01) 0.36 (0.25, 1.02)
σV (0.3) 0.37 (0.26, 0.59) 0.4 (0.26, 0.71) 0.36 (0.27, 0.73) 0.38 (0.25, 0.72) 0.37 (0.26, 1.07) 0.4 (0.26, 1.07)
σ (0.3) 0.31 (0.27, 0.35) 0.23 (0.16, 0.32) 0.31 (0.26, 0.35) 0.18 (0.13, 0.24) 0.3 (0.26, 0.35) 0.21 (0.15, 0.28)
w1 (0.65) 0.66 (0.62, 0.7) 0.62 (0.54, 0.7) 0.64 (0.56, 0.69) 0.55 (0.48, 0.61) 0.65 (0.56, 0.68) 0.57 (0.48, 0.64)
w2 (0.3) 0.28 (0.25, 0.32) 0.3 (0.24, 0.36) 0.3 (0.27, 0.33) 0.35 (0.3, 0.39) 0.3 (0.27, 0.31) 0.32 (0.28, 0.35)
w3 (0.05) 0.06 (0.04, 0.08) 0.07 (0.04, 0.13) 0.06 (0.03, 0.15) 0.11 (0.05, 0.17) 0.05 (0.02, 0.14) 0.11 (0.05, 0.2)
Ma (100) 92.6 (89.1, 95.1) 85.1 (79, 89.1) 91.1 (81.5, 94) 84.3 (76.8, 89.7) 95.1 (85.4, 97.1) 88.4 (79.3, 94.3)
a

M: Percent of correctly classified membership.