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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Can J Urol. 2011 Aug;18(4):5819–5825.

Table 2.

Induction of Apoptosis. Calculated concentrations of effective doses (ED) for sunitinib and pazopanib in inducing apoptosis against eight human renal cell carcinoma cell lines

Cell line Compound (μM) ED20 ED50 ED70 ED90
769-P Sunitinib 17.4 23.7 28.7 >40
Pazopanib >100 N/A N/A N/A
786-O Sunitinib 34.5 45.9 50.9 55.1
Pazopanib >100 N/A N/A N/A
HRC-24 Sunitinib 18.0 21.0 22.4 25.5
Pazopanib >100 N/A N/A N/A
HRC-31 Sunitinib 7.7 12.4 16.7 27.3
Pazopanib >100 N/A N/A N/A
HRC-45 Sunitinib 17.4 21.4 24.8 32.8
Pazopanib 76.1 N/A N/A N/A
HRC-78 Sunitinib 17.5 32.7 48.9 88.9
Pazopanib 80.6 N/A N/A N/A
SK-45 Sunitinib 23.2 29.6 34.3 43.4
Pazopanib >100 N/A N/A N/A
SK-26b Sunitinib 22.4 54.5 99.3 >100
Pazopanib N/A N/A N/A N/A