Figure 4. Phylogenetic tree for the C3-V3 genomic region of the recombinant BG sequences, sequences downloaded from the Los Alamos database and from Portuguese patients, showing the significant clustering of BG sequences and associated CXCR4 usage.

Sequences are labeled according to subtype and coreceptor usage, Sequences were either subtype G in pol and subtype B in env (circles), subtype B both in pol and in env (squares). If the sequences were subtype B only in env (no information available for pol), no label was added. Sequences colored green use CCR5 only, while sequences colored red can use CXCR4. Asterisk indicates significant support for the cluster (LRT >0.95). Tree was built as described in the methods section.