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. 2011 Sep 28;6(9):e25171. doi: 10.1371/journal.pone.0025171

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Pati et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Blood was drawn at two hours post-hemorrhage and analyzed for serum levels of TNFα, MCP-1, IL-10 and MIP-1α. As shown in Figures 5A–C, bioplex analysis of serum shows that MCP-1, TNFα, and MIP-1α all significantly increase after HS and HS+LR. This rise is significantly decreased by MSC administration (* indicates p<0.05 for HS vs. LR+MSC and LR vs. LR+MSC). Figure 5D shows that anti-inflammatory cytokine IL-10 is significantly increased by MSC (Figure 5D).