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. 2011 Sep 28;6(9):e25253. doi: 10.1371/journal.pone.0025253

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Roffman et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Both schizophrenia patients (a) and healthy participants (b) exhibited significant condition×genotype interactions (patients: F = 4.51, p = .042; healthy participants: F = 10.32, p = .004) indicating that C/C participants, but not T allele carriers, showed significant error-related dACC activation. (c) Pseudocolor statistical maps of the relationship between 677C allele load (0, 1, or 2 copies) and error-related activation (error minus correct) in the combined group, displayed on the inflated medial cortical surface. The dACC is outlined in green. Graphs illustrate the effects of allele load on error-related activation, averaged across vertices in the anatomically defined dACC, for patients and healthy participants. Error bars indicate the standard error of the mean.