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. 2011 Sep 28;6(9):e25416. doi: 10.1371/journal.pone.0025416

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Majumder et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Electron microscope sections obtained from CA1 regions of 15-month-old 3xTg-AD mice. Sections show examples of enlarged autophagosomes containing electron-dense undigested materials. Top-left panel: N = nucleus; the arrowhead points to the nuclear membrane; the arrows point to enlarged autophagosomes. Top-right panel: the arrowhead points to an autophagosome that does not contain undigested material. The arrow points to an autophagosome containing undigested material. Similar structures are also shown in the bottom two panels (arrows).