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. 2011 Sep 28;6(9):e25313. doi: 10.1371/journal.pone.0025313

Figure 6. TbRMI1 is required for both RAD51-dependent and RAD51-independent VSG switching.

Figure 6

(A) Simultaneous deletion of RMI1 and RAD51 severely impairs VSG switching. Overall VSG switching frequencies of wild type, rmi1, rad51, and rmi1 rad51 were plotted. (B) Increased VSG GC rate in rmi1 was dependent on RAD51, but RMI1 also functions in VSG GC switching independently of RAD51. (C) Increased crossover in rmi1 was dependent on RAD51. (D) ‘ES GC or ES loss’ switching was impaired in a rad51 or rmi1 single mutant. The results are also summarized in Table 1.