Table 7. Attenuation of spontaneous L-413C-resistant and defined LPS-affected mutants for BALB/c mice infected subcutaneously.
| Strain | LD50 (CFU) | Attenuation (fold) | Mean time to death (days) | MTD extension |
| CO92 (WT) | 3.3 | ― | 5.5 | ― |
| S-2 | ≥9.8×107 | ≥3.0×107 | >14.0 | >150% |
| S-7 | 1.7 | ― | 5.7 | ― |
| waaL | 44.4 | 13.5 | 5.8 | ― |
| waaF | 4.5×102 | 1.4×102 | 9.0 | 64% |
| hldE | 6.3×103 | 1.9×103 | 11.9 | 116% |
| waaA-1 | ≥1.3×107 | ≥3.9×106 | >14.0 | >150% |
| yrbH-1 | ≥3.4×107 | ≥1.0×107 | >14.0 | >150% |
| CO92 (WT)* | 2.2 | ― | 5.4 | ― |
| waaA-2 * | ≥8.0×106 | ≥3.6×106 | >14.0 | >150% |
| yrbH-2 * | ≥9.1×106 | ≥2.8×106 | >14.0 | >150% |
*Repeated experiment.