Table 1.
Identified transcriptional binding targets of the circadian gene NPAS2.
| Gene symbol | Gene name | NPAS2 binding region | Position to the gene TSSb | Brief functiona | Enrichment fold changes |
|---|---|---|---|---|---|
| ARHGAP29 | Rho GTPase activating protein 29 | chr1:094477485–094477544 | −(1590–1649) | Signal transduction, candidate tumor suppressor gene in MCL | 4.35 |
| BC033172 | Hypothetical protein | chr4:183299087–183299133 | 3’ end +(664–710) | Function unknown | 1.66 |
| BRDG1 | Signal transducing adaptor family member 1 | chr4:068107287–068107346 | +(246–305) | Downstream of Tec tyrosine kinase in B cell antigen receptor signaling | 149.01 |
| C1orf188 | Ring finger protein 207 | chr1:006191778–006191822 | +(3002–3046) | Function unknown | 1.28 |
| CADPS2 | Ca2+-dependent activator protein for secretion 2 | chr7:122313589–122313633 | +(157–201) | Calcium ion binding, exocytosis protein transport. It is related to hyperactive behavior and autism | 1.29 |
| CDC25A | Cell division cycle 25A | chr3:48205294–48205338 | −(489–533) | CDC25A is required for G1/S and G2/M transition. It is an oncogene | 3.26 |
| CDKN2AIP | CDKN2A (p16) interacting protein | chr4:184602132–184602177 | −(651–606) | Binds to p16, p53, and HDM2, and involved in cell cycle, senescence, and DNA damage response | 2.88 |
| CX3CL1 | Chemokine (C-X3-C motif) ligand 1 | chr16:55964583–55964627 | +(668–712) | Mediates antitumor immune response | 1.97 |
| DNAH2 | Dynein, axonemal, heavy chain 2 | chr17:7556327–7556371 | +(7437–7393) | Belongs to dyneins protein family, components of multisubunit motor ATPase complexes | 88.65 |
| ELF4 | E74-like factor 4 | chrX:129072521–129072565 | −(368–412) | Transcription factor. Candidate tumor suppressor gene, regulates cell cycle entry | 14.38 |
| GNAL | Guanine nucleotide binding protein, alpha activating | chr18:11738236–11738288 | +(58972–59025) | Cellular transformation and tumor development | 1.92 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | chr19:53589176–53589220 | −(2554–2598) | Intracellular signal transduction, deleted in gliomas | 2.10 |
| POU4F2 | POU class 4 homeobox 2 | chr4:147779300–147779344 | −(151–195) | Transcription factor expressed in human retina ganglion cells. Regulates CDK4, CCND1, and it facilitates breast cancer progression and invasion | 1.61 |
| RD3 | Retinal degeneration 3 | chr1:209731637–209731681 | +(1201–1245) | Gene transcription and splicing | 1.13 |
| REN | Renin | chr1:202402110–202402165 | −(22–77) | Involved in angiotensin maturation, regulation of blood pressure | 1.35 |
| THRA | Thyroid hormone receptor, alpha | chr17:35473541–35473585 | +(952–996) | Mediates activities of thyroid hormone, expression level altered in thyroid and breast cancer | 17.63 |