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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Mol Cancer Ther. 2010 Dec;9(12):3164–3174. doi: 10.1158/1535-7163.MCT-10-0078

Figure 6. Resistance to RA does not protect against etoposide, cisplatin, or melphalan cytotoxicity.

Figure 6

SMS-LHN and SMS-KCNR cell lines and the corresponding cell lines selected for retinoic acid resistance (SMS-LHN 12xRR, SMS-KCNR 12xRR) were treated with ETOP, CDDP, or L-PAM for 7 days. The drug concentrations used were, ETOP (µg/ml) 1.25, 2.5, 5, 10; CDDP (µg/ml) 0.1, 2, 5, 10 and L-PAM (µg/ml) 1, 3, 6, 9. Cytotoxicity was measured using a DIMSCAN system. Results are expressed as the fractional survival of treated cells compared to control cells. Parental cell lines are indicated by (graphic file with name nihms247042ig3.jpg) and RA-resistant cell lines are indicated by (■).Error bars indicate SD. Two-tailed t-tests were used to determine significant (p<0.05) differences between plots for the three highest drug concentrations. Asterisks indicate significant differences between responses.