Table 1.
Predictive Value of IL28B rs12979860 Genotype for Natural Clearance of Hepatitis C Virus Genotype 4
| rs12979860 Genotype | Allele frequency in those with spontaneous clearance (%) | Allele frequency in those with persistence (%) | Comparison | OR (95% CI) | P |
| C (n = 217) | 122 (76.3) | 95 (57.9) | C vs T | 2.3 (1.4–3.8) | .0005 |
| T (n = 107) | 38 (23.8) | 69 (42.1) | … | … | … |
| C/C (n = 73) | 48 (60.0) | 25 (30.5) | C/C vs T/T | 3.8 (1.3–11.5) | .0126 |
| C/T (n = 71) | 26 (32.5) | 45 (54.9) | C/C vs C/T | 3.3 (1.7–6.6) | .0005 |
| T/T (n = 18) | 6 (7.5) | 12 (14.6) | C/C vs C/T and T/T | 3.4 (1.8–6.5) | .0002 |
Of the 162 subjects in this study for whom the rs12979860 SNP was successfully typed, 80 of the subjects were associated with spontaneous clearance and 82 with persistence.
Abbreviations: CI, confidence interval; OR, odds ratio.