Table 2.
Cytokine Production by Peripheral Blood Mononuclear Cells Induced by Recombinant Sm-p80 After 48 Hours of Culture In Vitro
| Mean cytokine level (SD), pg/mL |
|||||
| Vaccine, baboon ID | Vaccine group | IL-2 | IL-4 | IL-10 | IFN-γ |
| Recombinant vaccine | |||||
| RE13 | Control ODN | 59.13 (0.00) | 123.84 (34.72) | 77.76 (11.85) | 121.92 (6.71) |
| WA84 | Control ODN | 60.48 (15.23) | 121.92 (15.11) | 73.92 (12.46) | 135.36 (21.93) |
| LA15 | Control ODN | 61.44 (10.00) | 117.12 (5.24) | 66.24 (4.63) | 95.68 (9.63) |
| GE35 | Control ODN | 58.56 (5.24) | 139.20 (11.03) | 71.04 (4.32) | 38.40 (3.33) |
| ST88 | rSm-p80 + ODN-10104 | 600.96 (6.13) | 252.80 (12.15) | 250.56 (35.55) | 723.84 (34.37) |
| NI31 | rSm-p80 + ODN-10104 | 635.52 (34.80) | 122.88 (5.00) | 258.24 (19.03) | 734.40 (44.30) |
| SE83 | rSm-p80 + ODN-10104 | 536.64 (18.89) | 160.64 (17.17) | 191 (12.86) | 981.12 (21.60) |
| AN25 | rSm-p80 + ODN-10104 | 486.72 (53.01) | 142.40 (18.69) | 204.48 (30.04) | 680.64 (9.47) |
| WA17 | Baboon albumin + R848 | 54.72 (11.22) | 44.80 (4.44) | 63.36 (9.69) | 119.04 (12.90) |
| IS21 | Baboon albumin + R848 | 56.64 (5.42) | 41.28 (12.40) | 66.24 (9.27) | 96.00 (9.65) |
| FE33 | Baboon albumin + R848 | 53.76 (6.57) | 38.08 (2.68) | 64.32 (4.29) | 167.04 (17.57) |
| TO41 | Baboon albumin + R848 | 59.52 (5.23) | 43.20 (7.92) | 49.92 (4.10) | 120.00 (18.57) |
| FR01 | rSm-p80 + R848 | 515.52 (19.66) | 144.00 (13.51) | 229.12 (11.62) | 750.72 (16.77) |
| HU22 | rSm-p80 + R848 | 571.20 (20.97) | 134.72 (6.08) | 122.88 (7.35) | 791.04 (27.96) |
| TA52 | rSm-p80 + R848 | 426.24 (15.13) | 140.48 (8.74) | 233 (19.74) | 821.76 (6.72) |
| OR46 | rSm-p80 + R848 | 534.72 (10.34) | 154.24 (15.89) | 186.24 (17.86) | 674.88 (14.56) |
| DNA-prime/protein-boost vaccine | |||||
| CA21 | VR-1020 + control ODN | 12.1 (0.23) | 10.44 (2.11) | 7.66 (1.50) | 11.10 (0.11) |
| TR02 | VR-1020 + control ODN | 8.88 (0.29) | 12.12 (1.13) | 9.22 (1.42) | 15.60 (1.13) |
| NA25 | VR-1020 + control ODN | 14.14 (1.00) | 17.13 (3.23) | 6.24 (4.63) | 9.88 (1.36) |
| KE04 | Sm-p80-VR-1020 + rSm-p80 + ODN-10104 | 358.51 (15.24) | 145.30 (11.00) | 69.08 (8.23) | 538.10 (13.93) |
| TA76 | Sm-p80-VR-1020 + rSm-p80 + ODN-10104 | 210.16 (16.31) | 42.83 (2.11) | 20.60 (5.50) | 123.40 (4.70) |
| CR03 | Sm-p80-VR-1020 + rSm-p80 + ODN-10104 | 335.20 (23.81) | 39.68 (3.01) | 28.41 (10.30) | 139.30 (15.20) |
| MA97 | VR-1020 + baboon albumin + R848 | 11.42 (1.20) | 14.30 (2.41) | 13.60 (2.90) | 20.04 (2.10) |
| TO04 | VR-1020 + baboon albumin + R848 | 16.40 (5.42) | 11.81 (2.10) | 17.40 (3.70) | 10.00 (1.51) |
| BR31 | VR-1020 + baboon albumin + R848 | 13.60 (1.17) | 8.80 (0.89) | 14.20 (1.29) | 17.14 (2.71) |
| KA03 | Sm-p80-VR-1020 + rSm-p80 + R848 | 389.21 (18.39) | 53.29 (3.29) | 49.49 (5.20) | 139.00 (8.70) |
| LE87 | Sm-p80-VR-1020 + rSm-p80 + R848 | 225.29 (17.60) | 44.10 (5.19) | 89.12 (10.29) | 254.82 (20.70) |
| VI18 | Sm-p80-VR-1020 + rSm-p80 + R848 | 191.30 (10.79) | 39.22 (5.98) | 32.18 (2.20) | 190.03 (21.60) |
The values represent the mean (SD) of 3 independent experiments.