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. 2011 Jun 14;19(9):1676–1687. doi: 10.1038/mt.2011.109

Figure 1.

Figure 1

On-target silencing activity of bulge-small interfering RNA (siRNA) depends upon position of bulge. (a) The sequence and structure of siRNAs targeting survivin mRNA and the corresponding hypothetical structures. The number in the siRNA nomenclature represents the position of the single nucleotide bulge (gray) from the 5′-end of the antisense sequence. (b) Bulge-modified siSurvivin show position-dependent silencing activity. HeLa cells were transfected with 10 nmol/l of siRNA targeting GFP expression (siGFP) or siSurvivin siRNAs. Results from real-time quantitative PCR (qPCR) are shown as mean ± SE from three independent experiments.