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. 2011 Jun 14;19(9):1676–1687. doi: 10.1038/mt.2011.109

Figure 4.

Figure 4

Bulge modification reduces off-target silencing of siMAPK. (a) Sequences of unmodified and modified siMAPK-14 with bulge and 2′-OMe modifications at position 2 of antisense strand. (b) IC50 values of MAPK14 small interfering RNAs (siRNAs). (c) On-target and off-target silencing of siMAPK-14 constructs at 10 nmol/l concentrations. (d) Average of fold discrimination between on- and off- target silencing of both the mismatched targets is shown for each siRNA at three different concentrations. For details see descriptions of Figure 3.