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. 2011 Sep 19;7:1299–1303. doi: 10.3762/bjoc.7.151

Table 1.

Synthesis of γ-oxo-amino acids.

graphic file with name Beilstein_J_Org_Chem-07-1299-i001.jpg

Entry 1 R Yield (%) 2 Yield (%)
Meth. Aa Meth. Bb

1 1a [26] CH3 92 2a 78 91
2 1b [26] CH2Cl 82 2b 75 90
3 1c [26] CH2OC6H5 86 2c 76 93
4 1d CH2O-(p-Cl-C6H4) 88 2d 72 82
5 1e CH2O-(o-NO2-C6H4) 84 2e 75 87
6 1f CH2O-(p-NO2-C6H4) 83 2f 74 84

aMethod A: Swern oxidation; bMethod B: DMP oxidation.