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. 2011 Oct;138(4):381–391. doi: 10.1085/jgp.201110660

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© 2011 Tiffert and Lew

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 5. — Comparison between patterns of calcium-induced nucleotide changes observed experimentally and predicted by the three-enzyme-model. (A) The experimentally observed pattern shown in Fig. 4 is reproduced to aid direct visual comparisons. (B–D) Selected model-derived patterns using the Ca²⁺ ATPase V_max and Km(ATP) parameter values shown in the figures and the default values reported in the Appendix for all the other parameters of the system. The rate of IMP breakdown to hypoxanthine, which is responsible for the decline in total nucleotide concentration, was set at 0.2 mmol/Lch in all simulations. (B) Best-fit parameter values for pattern reproduction. (C) Pattern rendered when using experimentally determined Km(ATP) values at high V_max. (D) Pattern rendered when using V_max–Km(ATP) values within measured ranges.