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. Author manuscript; available in PMC: 2011 Sep 29.
Published in final edited form as: Bioorg Med Chem Lett. 2008 Aug 29;18(20):5626–5630. doi: 10.1016/j.bmcl.2008.08.087

Figure 5.

Figure 5

Both PHCCC (3) and 7 shift the glutamate agonist response curves to the left 5.5- and 27.2 (±8.5)-fold, respectively at 30 µM (EC50 shifts from 7.5 ± 1.6 µM to 317 ± 100 nM). Interestingly, PHCCC increases maximal response whereas 7 affords no increase in the glutamate max, akin to other mGluR5 PAMs reported from our labs.7