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. Author manuscript; available in PMC: 2011 Sep 29.
Published in final edited form as: J Am Chem Soc. 2005 Oct 19;127(41):14401–14414. doi: 10.1021/ja052681+

Figure 1.

Figure 1

Figure 1

SRH of S-(−)-nicotine and DCEH of R-(−)-deschloroepibatidine binding to the α4β2 nAChR. (A) Viewing the SRH structure in the complex perpendicular to the fivefold axis. Only two subunits of the receptor are shown, along with the ligand in CPK mode. (B) Similar view for DCEH in the complex with the receptor. (C) Viewing the SRH structure (in stick) in the binding site oriented toward the α4 subunit. The pocket is represented in molecular surface format, colored with electrostatic potential in which blue represents positive charge and red represents negative charge; the front part of the pocket has been removed for clarity. (D) A similar view of DCEH at the α4β2 nAChR binding site.