. Author manuscript; available in PMC: 2011 Sep 29.

Published in final edited form as: J Am Chem Soc. 2005 Oct 19;127(41):14401–14414. doi: 10.1021/ja052681+

Table 2.

Key intermolecular distances involved in the hydrogen-bond (HB) and cation-π interactions in the microscopic binding complexes of several molecular species of S-(−)-nicotine and R-(−)-deschloroepibatidine with the α4β2 nAChR (R).

	HB distance (Å)	Cation-π distance (Å)
SRH-R	1.90	3.30
SRHH-R	1.82	3.39
DCEH-R	1.70	2.82, 2.72
DCEH2-R	1.84	2.69, 2.96
DCEa-R	1.91	2.69^*

no cation-π interaction.