. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Invest New Drugs. 2010 May 25;29(5):901–911. doi: 10.1007/s10637-010-9445-z

Table 3.

Hematologic and Non-hematologic tolerability of 48-hour PAC-1 CRI

Parameter	Reference	Day 0	Day 7	Day 14	Day 21
WBC	6–17.0×10³	8.2 ± 1.5	7.0 ± 0.4	7.0 ± 0.4	8.4 ± 0.6
Neutrophil	3–11.5×10³	5.4 ± 1.0	5.0 ± 0.5	4.3 ± 0.9	5.9 ± 0.3
Lymphocyte	1–4.8×10³	1.9 ± 0.3	1.3 ± 0.2	1.9 ± 0.7	1.5 ± 0.2
Hematocrit	35–52%	53.0 ± 3.8	55.4 ± 1.3	49.3 ± 6.0	50.6 ± 3.4
Platelet	2–9×10⁵	1.9 ± 0.4	1.8 ± 0.3	2.0 ± 0.4	2.2 ± 0.8
Creatinine	0.5–1.6 mg/dl	0.9 ± 0.2	1.0 ± 0.3	0.9 ± 0.1	1.0 ± 0.2
Calcium	7.9–11.5 mg/dl	10.3 ± 0.1	10.5 ± 0.3	10.2 ± 0.4	10.4 ± 0.4
Phosphorous	2.4–6.5 mg/dl	3.7 ± 0.4	2.9 ± 0.9	3.6 ± 0.3	3.4 ± 0.4
ALT	17–87 U/L	46.7 ± 34.1	57.0 ± 34.6	56.3 ± 46.7	49.7 ± 29.0