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. 2011 Jan 9;12(2):137–143. doi: 10.1038/ni.1979

Figure 5. Differences in the effect of type I interferon on the replication of MHV 2′-O-methyltransferase mutants.

Figure 5

(a,b) Kinetics of the replication of MHV-A59, MHV-Y15A or MHV-D130A in wild-type and Mda5-deficient mouse macrophages (1 × 106) after infection at an MOI of 1 (a) or 0.0001 (b). Data represent two independent experiments (mean ± s.e.m. of five samples). (c,d) Titer of MHV-A59, MHV-Y15A or MHV-D130A at 24 h after infection (MOI = 1) of wild-type (c) or Mda5-deficient (d) macrophages (1 × 105) pretreated with IFN-α (dose, horizontal axis) 4 h before infection. Data represent two independent experiments (mean and s.d. of four samples).