Figure 7. Deficiency in 2′-O-methyltransferase affects the recognition of virus by the innate immune system in vivo.

Viral titers in the spleen (a) and liver (b) of wild-type mice and mice deficient in IFNAR, Mda5 or TLR7 or both Mda5 and TLR7, assessed 48 h after infection with MHV-A59, MHV-Y15A or MHV-D130A (500 plaque-forming units injected intraperitoneally). Data represent two independent experiments (mean and s.d. of six samples).