Table 2. Results of prediction analyses.

Validation cohort	R g f	P g f	R g c	P g c
Lothian Birth Cohort 1921	0.098	0.014	0.133	1.3 × 10−3
Lothian Birth Cohort 1936	0.094	1.5 × 10−3	0.082	4.9 × 10−3
Aberdeen Birth Cohort 1936	0.067	0.11	0.049	0.16
Newcastle	0.137	7.5 × 10−5	0.057	0.06
Manchester	0.148	1.3 × 10−5	0.086	7.5 × 10−3
Mean	0.11		0.081
NCNG	0.076	0.028	0.092	0.009

For the CAGES samples each cohort, in turn, was used as the validation cohort and the predictor was generated from a joint analysis of the four remaining cohorts. A joint analysis of the five UK cohorts was used to create the predictor for the NCNG cohort. R is the correlation coefficient between the observed phenotype and the predicted value for each individual based on genetic information. P indicates the statistical significance (one-sided t-test, since the alternative hypothesis is that the predictor is positively correlated with outcome) of the correlation coefficient R.