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. 2011 Sep 19;108(39):16357–16362. doi: 10.1073/pnas.1100702108

Fig. 4.

Fig. 4.

Molecular modification of a proinflammatory TLR2 ligand to contain linoleate yields a TLR2 ligand with diminished inflammatory potential and inhibitory characteristics. Mice were evaluated using intravital microscopy for the number of neutrophils emigrated into the cremaster tissue. (A) Mice evaluated 4.5 h following intrascrotal injections of 150 μL of saline or saline containing FSL1-Lin2, FSL1-Ole2, or FSL1-Lnn2 (all at 5 ng/g) in comparison with the parent (R/S)FSL-1 ligands. (A) Mice evaluated during superfusion of the exposed cremaster with buffer containing MIP2 (2.5 μM) or MIP2 (2.5 μM) + FSL1-Lin2 (200 ng/mL). (C) Wild-type mice or MyD88−/− mice evaluated 4.5 h following intrascrotal injections of 150 μL of saline or saline containing FSL1-Lin2 (5 ng/g) and/or TNFα (20 ng/g) as indicated.