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Clustering characterized lethal compounds based on modulatory profiles. (A) Heat map of the similarity matrix showing the Spearman correlation between modulatory profiles of lethal compounds. (B) Dendrogram derived from hierarchical clustering of the similarity matrix in A. (C) TC-7 cells stained for acetylated tubulin after 60-min treatment with vehicle (DMSO), 5 μM rotenone, 1 μM colchicine, or 1 μM staurosporine. Representative images were chosen for each treatment.
