Table VI.

Significant changes in granuloma variables at 200 days post-infection for deletion and depletion of all TNF activity (“All TNF”), TNF effects on cellular transendothelial migration activity (“Recruitment”), and TNF-induced secretion of chemokines/TNF activity (“Secretion”) versus the baseline control scenario¹. Represenative granuloma structures for each deletion and depletion are shown. A full list of all simulated granulomas for ach deletion/depletion is given in Supplement 3.

¹+ denotes a higher variable value for the deletion or depletion than the control scenario; - denotes a lower value. +++ (p < 0.0001); ++ (p < 0.001); + (p < 0.01). Significant negative correlations: --- (p < 0.0001); -- (p < 0.001); - (p < 0.01).

²B_tot = B_e + B_i

³Number of T_γ cells actively secreting IFN-γ.