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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: J Med Chem. 2011 Aug 24;54(18):6364–6374. doi: 10.1021/jm2007744

Figure 5.

Figure 5

Dose-dependent effects of 22 on the protein (left panel) and mRNA (right panel) expression of YB-1 and its targets HER2 and EGFR in (A) PC-3 cells versus stable PC-3 transfectants expressing CA-ILK (PC-3/CA-ILK), and (B) SKBR3 cells versus transient SKBR3 transfectants expressing ectopic CA/ILK (SKBR3/CA-ILK). Cells were treated with 22 at the indicated concentrations in 5% FBS-supplemented medium for 24 h. These data are representative of three independent experiments. Blot on the left confirms the presence of the CA-ILK protein (*) in transfected SKBR3 cells.