Skip to main content
. Author manuscript; available in PMC: 2012 Sep 16.
Published in final edited form as: Circ Res. 2011 Aug 11;109(7):729–738. doi: 10.1161/CIRCRESAHA.111.247148

Figure 1.

Figure 1

Camui is a FRET biosensor based on the structure of CaMKII. (A) Binding of Ca2+/CaM results in a conformational shift that increases the distance between the N-terminal catalytic domain and the C-terminal regulatory/association domains, reducing FRET between the CFP/YFP pair. (B) Titration of Camui with CaM in the presence of saturating Ca2+ shows the dynamic range of the sensor.