Table 3.
Relative proportion of BrdU+Ki67− cells (mean + SEM) that were distributed within the proliferative (VZ/SVZ) and postmitotic (IZ/CP) regions of the cerebral wall of saline- or cocaine-exposed embryos
| Age | Cortical region | Cytoarchitectonic zone | Saline | Cocaine |
|---|---|---|---|---|
| E13 | PFC | VZ/SVZ | 37.73 ± 6.79 | 67.29 ± 9.46* |
| IZ/CP | 62.27 ± 6.79 | 32.71 ± 9.46* | ||
| MPFC | VZ/SVZ | 65.10 ± 2.23 | 77.70 ± 4.71* | |
| IZ/CP | 34.90 ± 2.23 | 22.30 ± 4.71* | ||
| E15 | PFC | VZ/SVZ | 79.45 ± 2.00 | 69.70 ± 6.55 |
| IZ/CP | 20.55 ± 2.00 | 30.30 ± 6.55 | ||
| MPFC | VZ/SVZ | 87.48 ± 6.19 | 91.70 ± 3.05 | |
| IZ/CP | 12.52 ± 6.19 | 8.3 ± 3.05 |
The proportions are expressed as percentages of the total numbers of BrdU+Ki67− cells within the cerebral wall. The boundaries between the different zones are approximate and were identified based on histological criteria.
*p < 0.05.