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. 2011 Sep 29;7(9):e1002160. doi: 10.1371/journal.pcbi.1002160

Table 1. Parameter sets (P1 and P2) adapted to the response patterns of two INs (IN1 and IN2).

Parameter Description gdend/gsoma * ) P1 P2
Vrest Resting potential -63 mV -69 mV
Rm Membrane resistance 22 kΩcm2 45 kΩcm2
Cm Membrane capacitance 1.1 µF/cm2 1.1 µF/cm2
Ra Axial resistivity 113 Ωcm 113 Ωcm
RIN Total input resistance 240 MΩ 470 MΩ
τm Membrane time constant 24 ms 50 ms
gNa Max. Na-conductance in soma 0.1 0.09 S/cm2 0.09 S/cm2
ShNa ** ) Shifts in Na-kinetics +10.4 mV +12.7 mV
gKdr Max. Kdr -conductance in soma 0.1 0.37 S/cm2 0.5 S/cm2
ShKdr ** ) Shifts in Kdr –kinetics +11.8 mV +15 mV
gCaT Max. CaT-conductance in soma 1+0.04·x 1.2·10−5 S/cm2 8.5·10−6 S/cm2
gCaL Max. CaL-conductance in soma 0.25 9·10−4 S/cm2 1.3·10−3 S/cm2
gh Max. Ih-conductance in soma 1 1.1·10−4 S/cm2 1·10−5 S/cm2
gAHP Max. IAHP-conductance in soma 0.1 6.3·10−5 S/cm2 1.3·10−4 S/cm2
gCAN Max. ICAN -conductance in soma 1+0.04·x 2·10−8 S/cm2 1·10−7 S/cm2

*) Ion-channel distributions are described as the ratio between dendritic and somatic maximum conductance values. Ion channel density was assumed to be uniform over the dendrites, except for CaT and ICAN, where the densities were assumed to increase linearly with distance (x [µm]) from the soma.

**) Shifts are given in the positive direction along the voltage axis, and relative to the kinetics curves in Traub et al. 1993.