Table 1. Parameter sets (P1 and P2) adapted to the response patterns of two INs (IN1 and IN2).
Parameter | Description | gdend/gsoma * ) | P1 | P2 |
Vrest | Resting potential | -63 mV | -69 mV | |
Rm | Membrane resistance | 22 kΩcm2 | 45 kΩcm2 | |
Cm | Membrane capacitance | 1.1 µF/cm2 | 1.1 µF/cm2 | |
Ra | Axial resistivity | 113 Ωcm | 113 Ωcm | |
RIN | Total input resistance | 240 MΩ | 470 MΩ | |
τm | Membrane time constant | 24 ms | 50 ms | |
gNa | Max. Na-conductance in soma | 0.1 | 0.09 S/cm2 | 0.09 S/cm2 |
ShNa ** ) | Shifts in Na-kinetics | +10.4 mV | +12.7 mV | |
gKdr | Max. Kdr -conductance in soma | 0.1 | 0.37 S/cm2 | 0.5 S/cm2 |
ShKdr ** ) | Shifts in Kdr –kinetics | +11.8 mV | +15 mV | |
gCaT | Max. CaT-conductance in soma | 1+0.04·x | 1.2·10−5 S/cm2 | 8.5·10−6 S/cm2 |
gCaL | Max. CaL-conductance in soma | 0.25 | 9·10−4 S/cm2 | 1.3·10−3 S/cm2 |
gh | Max. Ih-conductance in soma | 1 | 1.1·10−4 S/cm2 | 1·10−5 S/cm2 |
gAHP | Max. IAHP-conductance in soma | 0.1 | 6.3·10−5 S/cm2 | 1.3·10−4 S/cm2 |
gCAN | Max. ICAN -conductance in soma | 1+0.04·x | 2·10−8 S/cm2 | 1·10−7 S/cm2 |
*) Ion-channel distributions are described as the ratio between dendritic and somatic maximum conductance values. Ion channel density was assumed to be uniform over the dendrites, except for CaT and ICAN, where the densities were assumed to increase linearly with distance (x [µm]) from the soma.
**) Shifts are given in the positive direction along the voltage axis, and relative to the kinetics curves in Traub et al. 1993.