Table 1.
Study | Mouse model | Age (mo) | Histopathology | Cognition | ||
---|---|---|---|---|---|---|
Aβ | CAA | Micro-hemorrhage | ||||
Passive immunization | APPSw | 19-22 | ↓60% | ↑ 4-fold | ↑ 6-fold | Improved |
Active vaccination | APPSw/ NOS2-/- |
12-16 | ↓85% | No change | ↑ 10-fold | Reversed |
Study | Mouse model | Age (mo) | Histopathology | Cognition | ||
---|---|---|---|---|---|---|
Aβ | CAA | Micro-hemorrhage | ||||
Passive immunization | APPSw | 19-22 | ↓60% | ↑ 4-fold | ↑ 6-fold | Improved |
Active vaccination | APPSw/ NOS2-/- |
12-16 | ↓85% | No change | ↑ 10-fold | Reversed |